MEDICATIONSUMANSPharmokineticsstudyofabsorptiondistributionmetabolismaexcretionADME inthehumanbodyknowledgeofhowmedicationsworkinthebodytheireffectsonspecificorganstheirintendedactionsaadversemedreactionsAbsorptionmovementofmedicationfromwhereitwasadministeredentersthebodytothecirculatorysystemaffectsthespeedaintensityofthemealactioninthebodyfactorsaffectingrateofabsorptionorouteofadministrationpointwheremedentersbodyoionizationthepitofmedicationasiteofabsorptionodissolutionmedicationmustbedissolvedbeforeabsorptionhappensobloodflowmedsareabsorbedfasterwherebloodflowisnigholipidsolubilitymedformulationcaneitherhavehighorlowlipidsolubilityosurfaceareaofabsorptivesiteoclientspecificfactorspathophysiologicalprocessesdiseaseinjuryageetcDistributionprocesstothetargetorgansitissuesfollowingabsorptionintocirculatorysystemaffectedbyclientscirculatorystatusorbloodflowmeassolubilityaproteinbindingabilityonianitvascularizedareasrelievegreatestbloodsupplyoneart oliverobrain okidneyolowvascularizedareasbonesskinadiposetissueMetabolismBiotransformation chemicalprocessofconvertingamedicationsstructurecanresultinamplifiedmedicationactivityinactivationofmedsorincreasedexcretionviakidneysacantoxicitylevelsofmedsme9181Emigrantgift Yferentimescytochromep.uao toactiveainactivesubstancestoallowfortheirexcretionoptswkidneyaliverdiseasemayhaveslowrateofmedicationclearancemaytransformspecificmedstoanotherform moreactiveorpotentformocodeinemorphineresultinginapainreliefprodrugsinactivechemicalsthatareactivatedthroughmetabolismtoexerttherapeuticaffectsfirstpasseffectcanresultinlowerconcentrationofmedicationreachingsystemiccirculationif amalorityofthemedicationhasalreadybeenmetabolizedintoaninactiveformbeforeitentersthebloodstreamknowledgeiscrucialfordeterminingappropriaterouteCypenzymesfoundonlivercellsplayaroleonmedicationmetabolismobyregulatingrateatwhichamedicationisbrokendownatheamountoftimemedicationstaysinbodyNutrientscaninfluencemedicationmetabolismExcretionprocessthatmedicationisremovedfrombodykidneysareprimaryorganrateofmedexcretionisaffectedbykidneyheartaliverfunctioninfluencemedconcentrationinbodymedicationtoxicitywhenboatisunabletometabolizeaexcreteamedomaycauseirreviversabledamagetoorgans MedicationpreperationpharmocodynamicsstudyofnowmedworksitsrelationshiptomedicationconcentrationanowbodyrespondsthreatentherapeuticdrugmonitoringTDM methodusedbyhealthcareproviderstomonitormedicationconcentrationinPtbloodousedformedsthathavenarrowtherapeuticwindow safewocausingadversemedreactionpeakandtroughbloodlevelshelpmaintaintherapeuticmedlevelsopeakbloodlevelswhenmedisathighestconcentrationbutbelowtoxiclevelooccurwhenabsorptioniscompleteotroughbloodlevelslowestlevelofconcentrationofmedthatcoorelatestorateofeliminationomeasuredbeforeadministratingnextscheduleddosehalflifetimeittakesformedicationtofailtohaltit strengththroughexcretionomedicationswithlongerhalflifemaybeadministeredoncedailytomaintaintherapeuticlevelodiarapamhalflife20honoursAdversedrugreactionsunintendedanontherapeuticeffectsofmedicationcanrangefromtolerabletoharmfuladversedrugeventlifethreateningmedicationreactionthatrequiresmedicalinterventiontopreventdeathpermanentdisabilitycongenitalanomalyorcausesprolongshospitalizationomustbereportedtoFDAsoagencycanimprovesafetyoutcomesreviselabels warningsawithdrawmedfrommarkeAllergicreactionswhenbodyperceivesmeaas aforeignsubstancestimulatinganimmuneresponseAnaphylaxisseverereactioninwhichimmuneresponsecausesdyspneahypotension tachycardiaStevenJonneonsyndromeSTsor14daysfollowingadministrationorespiratorydistressfeverchillsdiffusefinerashfollowedbyblistersMedicationinteractionsarugdruginteractionseffectthattwoormorearrasthatPtisadministeredhaveoneachotherointeractionsmayincludeintensityinatheeffectsofoneofthemedsordecreasingaffectsofoneofmedsdrugfoodinteractionseffectsofnutrientsontheADmeofmedicationsdrugherbalsupplementinteractionseffectssimilartodrugdrugFactorsaffectingmedactionsteratogenicmedicationsthatcancausefetaldefectspregnancylossprematurityordevelopmentaldisabilitiesococaine onceinhibitorsoalcohol ogentamicinonsaid otetracyline