antihyperlipidemia drugshyperlipidemia excess lipids in bloodLIPIDSFAT STEROLS PHOSPHOLIPIDSTRIGLYCERIDES CHOLESTEROLEMULSIFIERS LIPIDBILAYERconsumed storedfat fat lecithin membranescell theaths hormonespygmymembranes bilelipoproteins serveascamerstotransportlipidsin blood apolipoprotein apo B 100 carrylipidsintoarterywallformofLDL mutationscausefamilialhypercholesterolemiaLDL VLDL chillomicrons HDLlowdensitylipoprotein verylowdensitylipoprotein formedin intestinecarrytriglyceridesofdietary cholesterol primarycorecomponentsecretedbyliver originunearnedcholesterol momcontainsapoB100 exporttriglyceridestodegradationofVinhcholesterylesters peripheraltissues TgfromPERIPHERALtisones containapoB100Cholesterol lipid responsible forpropercellmembranesynthesisformation of bile acidssteroidhormonesprimarily produced in liverINSOLUBLE inwater mustbeboundtolipoproteinsfortransportationtriglyceride mainlipidcomponentofdietaryfat fatdepositsofanimalsexcess stored in adipocytessourceofenergyforbodyINSOLUBLE in water mustbeboundto lipoproteinsfortransportationoptimallevelsin therapeuticlifestyle Asdiet everything in moderationtotal cholesterol1200mg all Do NOT replaceneedfordmtherapyLDL C E 100mg allpts w anyform of ASCVDtriglycerides I 150mglot opts w primary LDL c 2190mglolopts w diabetesmellitus 407540HDL I 60mg d L opts w est 10yearASCVD risk 75 CholesterolsynthesisHMGCOA Reductase Inhibitors upregulatesLDLreceptors onhepatocytesMODEST triglyceridescompetitiveinhibitors ofHMGCoAreductase ratecontrollingenzyme ofthemetabolicpathwaythatproducescholesterolQPMstatin 1HMGCoAreductase cholesterolsynthesisinhibited intracellularcholesterol in cellsurfaceLDLreceptors bind internalizecirculating LDL C plasmacholesterollowerstheriskofAcrdzeventsplasmacholesterol iris inalltypesAVOID grapefruitmay not beeffectivefor homozygous familialhypercholesterolemia lacksLDLreceptorscontraindicationspregnancylactationactivechronicliverdzredyeastrice containsstatinactivitynephrotonictoxicities AETliverenzymesmyopathy rhabdomyolysisphotosensitivityMay T WARFARINeffectGI upsetHÉÉinÉns y more'rÉÉn n i contintensitiATORVASTATINLipitor SIMVASTATNIZOCOV LOVASTATIN MealormetabolizedbyCYP4503All takewithmealsROSUVASTATIN Crestor inhibitorsmayTrisk of immediatereleasetriglycerides rhabdomyolysis AVOIDGrapefruitjuicetreatstriglyceridesLDL tLDL totalcholesterol PRAVASTATIN