Antihypertensives
DIURETICS
enhancewater Natexcretion depends on mon for other salts
blood volume w drug waterexcreted in urine
leadsto BP
thiazide loopdiuretics Nat Kt delivery to distal nephron segment P Nat Kt loss
Ktsparingdiuretics Na Excretion Ktretention pairw thiazide orloopto mitigate
Distal Tubule DiureticsmA Loop Diuretics acute k sparingDiuretics
inhibit Nat Cl reabsorp
Ingist mtybualgreecrey.ionddwresis inhibitcholesterol reabsorp
amore inhibitKtsecretion influence
NatexcretioninDISTALTUBULESITEOFACTIONLoopofHenle Ktlossmurine
hypokalemia hyperkalemia
HYDRACHLOROTHIAZIDE dehydration anuriatriamterene rare
dosedependentototoxicity
prototypicalstartingagent hyponatremia SPIRONOLACTONE Aldactone
HTN hypotension aldosteronereceptorantagonistchronicedema
idiopathichypercalcuria hyperglycemia prevents Nareaboorp Ktsecretion
Caox stones
Meniere'sDz ppl FUROSEMIDE Lasik tandrogenreceptorblockerconvernontot
absorbed rapidly
d
canbe real thiazides
highpotassium lossinurine inhibits edema in HF
digitalislithiumtoxicity c reabsorption ascites cirrhosisnephroticsynd.r
hypokalemiasteroidsACTH LOW GFR hypertensive emergenciesto resistant HTN
hypouncemia mobilizelargevolumesoffluid primary huperaldosteronism
Pippengtroenmicortnostattowiaggarrisinariontijts toxicityotototonelnephrotoxicangsa acne hirsutism
lithium gynecomastia
inhibitedbyProbenecid Inotomethacin
hypercalcemiaAVOIDpastth gout
hyperglycemia
cautionsulfaallergies
EPLERENONE InspraCHLORTHALIDONE N BUMETANIDELBUMEN
long'slifebbioavail aldosteronereceptorantagonist
excreted in unneunsed MOSTPOTENTloopdiuretic HFedema
noototoxicity resistantHTNlargedosesseveremyalgiasMETOLAZONE cautionsulfaallergy primary hyperaldosteronism
LOW GFR hypertensiveemergenciesto LESSnsk for boobs
www mobilizelargevolumesoffluidcessfluid in HF
TORSEMIDE TRIAMTERENE Dyrenium
safetousew renalissues
distaltubuleNatchannel innit
INDAPAMIDE blocksNatKtCl carrier inthick
ascendingloop W thiazide tote HTN
uncommon Cantt HTN HaDizziness edemafrom variouscauses
decompensated HF LOW GFR hypertensiveemergenciesto turnspeeblueundergoes HEPATICmetaboexcreted
inurine bile crystalluria castformation
renalBF caution
Carbonic Anhydrase Inhibitors Osmotic Diuretics AMIloriDElmidamore
inhibitsenzymecarbonicanhydrase distaltubuleNatchannelinhibitor
inproximalrenaltubule renalexcretion promotesdiuresis'mkidneys by CT directly Natexcretion K'secretion
ofNatktbicarbonate water ofkidneyfiltratesblockingreabsorb of 3rdor4thlinetote hypertension or
metabolicacidosis waterbykidneytubules glomerulusprox HF compensateforktlossbyother
renalstones convolutedtubule diureticshyperammonemiaincirrhosis HA Nauseadizziness ascitesusedmoreoftenforpharmactionsthanas a polydipsia polyuriapolydipsia lithiumdiabetes
confusion AAmaycorrectmetabolicalkalosisbyotheran
bnetacidsecretion hypercholemicmetau
diuretic teeth're
many go peggygoy y morerapidonsetthenACETAZOLAMIDE DiamOX POOR chestPam diabeticsglucoseintolerance
IV
thot chronicopen angleglaucoma pressure ineyes glaucomaprophylaxis ofaltitudesickness increasedintracranialpressure
90 proteinboundeliminatedrenally
caution sulfaallergies lithiumtoxicity lithiumexcretion
initially centralvenouspressure
induce HF